Acylated derivatives of cytidine-diphosphate-choline,...

Details Acylated derivatives of cytidine-diphosphate-choline,... Acylated derivatives of cytidine-diphosphate-choline,...

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/10 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1259987

ABSTRACT OF THE DISCLOSURE Derivatives of cytidine-diphosphate-choline of the following formula: Image in which R represents an acyl radical chosen from the group comprised of saturated and unsaturated, linear or branched, monocarboxylic fatty acids having from 3-7 carbon atoms, and R1 represents H or an acyl radical identical to R, show a thera- peutic activity analogous to that of cytidine-dlphosphate-choline and are suitable for oral administration in that they lead to a gradual release of the active principle in the gastrointestinal tract. The compounds that respond to these requirements are mono-, di- and tri-acyl derivatives of CDP-choline that can be synthetized by acylation of CDP-choline with carboxylic acids using N,N'-carbonyldiimidazole.

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