C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/228
C07H 7/06 (2006.01) C07D 407/04 (2006.01) C07H 15/06 (2006.01)
Patent
CA 1041493
Abstract of the Disclosure Novel compounds which are N- and 0-acylates of pyrazofurin are described herein. A novel process for the preparation of the mono-N1-acylates comprises reacting pyrazofurin with an acylating agent under non-basic con- ditions in an organic solvent. The mono-N1-acylate so formed is further acylated under weak basic conditions to provide a tetra-acylated or penta-acylated pyrazofurin derivative, depending upon the duration of reaction. Mild solvolysis of either a tetra-acylate or a penta-acylate provides a tri-acylated pyrazofurin derivative. In the presence of a strong base, the mono-N1-acylate is further acylated to provide different tetra-acylates or penta- acylates of pyrazofurin, again depending upon the duration of reaction. Pyrazofurin acylates are useful as antiviral, antipsoriatic, antitumor and antifungal agents, as well as intermediates for new C-nucleosides.
227019
LandOfFree
Acylated derivatives of pyrazofurin and process for their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acylated derivatives of pyrazofurin and process for their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acylated derivatives of pyrazofurin and process for their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-202008