Acylated enol derivatives of .alpha.-ketoesters and...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/023 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/02 (2006.01) C07K 5/062 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2239159

This invention relates to acylated enol derivatives of .alpha.-ketoesters and .alpha.-ketoamides. The compounds of this invention are either prodrugs of known elastase inhibitors or are elastase inhibitors in their own right and are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema.

Les composés de la présente invention sont soit des bioprécurseurs d'inhibiteurs d'élastase connus, soit des inhibiteurs d'élastase à part entière, et sont utiles dans le traitement de diverses maladies inflammatoires, dont la fibrose kystique et l'emphysème.

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