Acylated insulin analogs

Details Acylated insulin analogs Acylated insulin analogs

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2205060

The present invention relates to the field of diabetes. More particularly, the invention relates to a monomeric insulin analog wherein the A chain is the naturally occurring sequence of the human insulin A chain and the B chain is modified at either position B28 and B29 or both. The analog is mono-acylated at the N-terminal of the A chain or B chain or at the lysine. The acylated insulin analogs have an extended duration of action.

La présente invention concerne le domaine du diabète. Plus précisément, elle porte sur un analogue monomère de l'insuline dans lequel la chaîne A est la séquence naturelle de la chaîne A de l'insuline humaine, et la chaîne B est modifiée en position B 28 ou B29 ou bien dans les deux positions à la fois. L'analogue est monoacylé à l'extrémité N de la chaîne A ou de la chaîne B, ou bien encore à la lysine. Les analogues de l'insuline acylés ont une durée d'action prolongée.

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