Acylated piperidine derivatives as melanocortin-4 receptor...

Details Acylated piperidine derivatives as melanocortin-4 receptor... Acylated piperidine derivatives as melanocortin-4 receptor...

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2573714

Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Selon l'invention, certains nouveaux dérivés de la pipéridine n acylés sont des agonistes des récepteurs de la mélanocortine humaine et, en particulier, des agonistes sélectifs du récepteur de la mélanocortine 4 (MC-4R). Lesdits dérivés sont utilisés pour le traitement, la régulation ou la prévention de maladies et de troubles responsables de l'activation de la MC-4R, tels que l'obésité, le diabètes, le dysfonctionnement sexuel, notamment les troubles de l'érection et les troubles sexuels féminins.

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