C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/5383 (2006.01) C07D 401/08 (2006.01) C07D 498/18 (2006.01)
Patent
CA 2664245
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
La présente invention concerne de nouveaux dérivés de spiropipéridine N-acylés en tant que ligands du ou des récepteurs humains de la mélanocortine et, en particulier, en tant que ligands sélectifs du récepteur humain de la mélanocortine-4 (MC-4R). Les dérivés se révèlent ainsi utiles pour le traitement, la régulation ou la prévention de maladies et de troubles sensibles à la modulation du MC-4R, tels que l'obésité, le diabète, la dépendance vis-à-vis de la nicotine, l'alcoolisme, le dysfonctionnement sexuel, y compris une dysfonction érectile et une dysfonction sexuelle féminine.
Bakshi Raman K.
Dellureficio James P.
Hong Qingmei
Jian Tianying
Liu Jian
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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