Acylated spiropiperidine derivatives as melanocortin-4...

Details Acylated spiropiperidine derivatives as melanocortin-4... Acylated spiropiperidine derivatives as melanocortin-4...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/438 (2006.01) A61K 31/5386 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 15/10 (2006.01) C07D 221/20 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 491/107 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2625877

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

La présente invention concerne certains nouveaux dérivés de spiropipéridine acylés qui sont des ligands du ou des récepteurs de mélanocortine de type humain et, plus particulièrement, des ligands sélectifs du récepteur de mélanocortine-4 de type humain (MC-4R). Ces dérivés sont donc utiles pour le traitement, le contrôle ou la prévention des maladies et des troubles qui peuvent réagir à la modulation du MC-4R, tels que l~obésité, le diabète, l~addiction à la nicotine, l~alcoolisme, le dysfonctionnement sexuel, y compris le dysfonctionnement de l~érection et le dysfonctionnement sexuel chez la femme.

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