Acylated spiropiperidine derivatives as melanocortin-4...

Details Acylated spiropiperidine derivatives as melanocortin-4... Acylated spiropiperidine derivatives as melanocortin-4...

C - Chemistry, Metallurgy

07

D

C07D 491/20 (2006.01) A61K 31/438 (2006.01) A61K 31/4545 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 15/10 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2624030

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Certains nouveaux dérivés spiropipéridines acylés sont des ligands des récepteurs humains de la mélanocortine-4 (MC-4R). Ils conviennent donc pour le traitement de, la lutte contre, et la prévention d'affections et de troubles réagissant à la modulation de MC-4R, et notamment l'obésité, le diabète, la dépendance nicotinique, l'alcoolisme et les difficultés sexuelles y-compris les troubles de l'érection chez l'homme et les troubles de l'excitation sexuelle chez la femme.

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