Acylation process for the synthesis of hmg-coa reductase...

Details Acylation process for the synthesis of hmg-coa reductase... Acylation process for the synthesis of hmg-coa reductase...

C - Chemistry, Metallurgy

07

F

260/357, 260/279

C07F 7/08 (2006.01) C07D 309/30 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1317295

TITLE OF THE DISCLOSURE A NOVEL ACYLATION PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS. ABSTRACT OF THE INVENTION A novel acylation process using an alkali metal bromide and a dialkylaminopyridine to form a sterically hindered ester functionality from an alkanoyl chloride and an alcohol is disclosed. The process of the present invention is used to prepare compounds of the formula:

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