Acylhydrocarbylaminoalkanoic acids, their production and use...

Details Acylhydrocarbylaminoalkanoic acids, their production and use... Acylhydrocarbylaminoalkanoic acids, their production and use...

C - Chemistry, Metallurgy

07

K

260/518, 260/525

C07K 5/02 (2006.01) A01N 37/12 (2006.01) C07D 211/76 (2006.01)

Patent

CA 1123433

Abstract Compounds of the formula Image ; wherein R1 is aliphatic or alicyclic hydrocarbyl or optionally substituted phenyl; R2 is hydrogen or aliphatic hydrocarbyl; R3 is hydrogen,alkyl, cycloalkyl, optionally substituted phenyl or, with R4, alkylene; R4 is alkyl, cycloalkyl, optionally sub- stituted phenyl, optionally substituted phenalkyl or, with R3, alkylene; or R2, R3 and R4, together with the carbon to which each is bond, are adamantyl; and n is 3, 4 or 5; and salts there- of with a base are pharmacologically active. Physiologically- acceptable embodiments are administered, e.g.. in the form of an appropriate pharmaceutical composition to warm-blooded animals for protection against and treatment for stomach, intestine, pan- creas, bile and liver disorders. Syntheses of pharmacologically- active components, compounding such principles into pharmaceu- tical compositions and using such principles for preventing and treating the noted disorders are described.

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