Acylindole derivatives and process for producing thereof

Details Acylindole derivatives and process for producing thereof Acylindole derivatives and process for producing thereof

C - Chemistry, Metallurgy

07

D

167/240, 260/319

C07D 209/12 (2006.01) A61K 31/40 (2006.01)

Patent

CA 1331604

Abstract The present invention is concerned with novel acylindole derivatives of the formula (I), process for producing thereof and platelet-aggregation inhibiting agents containing them as an active ingredient. Image (I) In the formula (I), each of R1 and R2 which may be the same or different is a hydrogen atom, lower alkyl group having 1 to 5 carbon atoms, lower alkyl group substituted by one or more hydroxy groups having 1 to 5 carbon atoms, or group of the formula -?-R3 in which R3 is a lower alkyl group having 1 to 5 carbon atoms, and -OR2 is a substituent at the o- or p- position, provided that -OR2 is not -OCH3 at p-positlon when R1 is hydrogen. Acylindole derivatives and pharmaceutically acceptable salts of the invention have an excellent inhibitory effect on platelet-aggregation as well as low toxicity. They can be administered either orally or parenterally. Therefore, the compounds of the invention are useful not only as preventive medicines or remedies for various diseases or symptoms caused by platelet-aggregation, but also as inhibitors of platelet-aggregation on vascular walls during or after surgery.

463386

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