C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/22 (2006.01) A61K 31/195 (2006.01)
Patent
CA 2536257
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (.plusmn.) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof , methods of making prodrugs of (.plusmn.) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (.plusmn.) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (.plusmn.) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
De manière générale, la présente invention a trait à des prodrogues à base de carbamate d'alkyle acylé de l'acide butyrique de (?) 4-amino-3-(4chlorophényle) et leurs analogues, à des compositions pharmaceutiques en contenant, à des procédés de fabrication de prodrogues de l'acide butyrique de (?) 4-amino-3-(4chlorophényle) et leurs analogues, et à des compositions pharmaceutiques en contenant pour le traitement ou la prévention de maladies communes et/ou de troubles communs tels que la spasticité et/ou la maladie de reflux d'acide. L'invention a également trait à des prodrogues à base de carbamate d'alkyle de l'acide butyrique de (?) 4-amino-3-(4chlorophényle) et leurs analogues aptes à l'administration orale et leurs formes de dosages orales à libération prolongée.
Gallop Mark A.
Ludwikow Maria J.
Peng Ge
Phan Thu
Yao Fenmei
Smart & Biggar
Xenoport Inc.
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