Acyloxymethyl esters of bisphosphonic acids as bone...

Details Acyloxymethyl esters of bisphosphonic acids as bone... Acyloxymethyl esters of bisphosphonic acids as bone...

C - Chemistry, Metallurgy

07

F

167/208, 167/250

C07F 9/40 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/58 (2006.01) C07F 9/59 (2006.01)

Patent

CA 2024694

The invention relates to acyloxymethyl esters of bisphosphonic acids, halo-bisphosphonic acids and hydroxy-bisphosphonic acids which exhibit oral bioavailability and are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.

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