Acyloxypropanolamines

Details Acyloxypropanolamines Acyloxypropanolamines

C - Chemistry, Metallurgy

07

C

167/207, 167/248

C07C 233/17 (2006.01) C07C 219/06 (2006.01) C07C 219/12 (2006.01) C07C 233/18 (2006.01) C07D 295/215 (2006.01) C07D 307/24 (2006.01)

Patent

CA 2005372

-16- TITLE ALKYLOXYPROPANOLAMINES ABSTRACT OF THE DISCLOSURE Compounds of the present invention, are represented by the general formula Image wherein R represents a straight or branched loweralkyl from 1 to about 6 carbon atoms, loweralkene from 2 to about 6 carbon atoms, or Image where m is o or 1 and n is 2, 3, 4, or 5 provided that when m is o, n is 2, 3, 4, or 5 and when m is 1, n is 3 or 4, and R1 is hydrogen, a straight, branched or cyclic loweralkyl from 1 to about 6 carbon atoms or loweralkoxy, phenyl or substituted phenyl, and R2 represents a straight or branched loweralkyl from 1 to about 6 carbon atoms or W-B wherein W represents alkylene of from 1 to about 10 carbon atoms which may be substituted with loweralkyl of from 1 to about 4 carbon atoms; and B represents hydrogen, -NHCOR4, or -NHCONR3R4, wherein R3 and R4 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, phenyl or aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl which may be unsubstituted or substituted with lower alkyl from 1 to about 6 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, hydroxy, hydroxyalkyl of from 1 to about 10 carbon atoms; thiophenyl, imidazole, oxazole or indole, furanyl, tetrahydrofuranyl or R3 and R4 may together with N form a pyrrolidino, piperidino, piperazino, or morpholino ring, or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorder or in the treatment of glaucoma.

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