C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/337 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) C07D 207/34 (2006.01) C07D 207/416 (2006.01) C07D 209/42 (2006.01) C07D 401/06 (2006.01) C07D 403/00 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2262847
New antiphlogistic and analgesic agents are disclosed having the formulas (I) and (II). These new compounds have an improved inhibiting effect and/or less cytotoxicity as compared with the compounds known from the prior art. The disclosed compounds are remarkably suitable to prevent and/or treat diseases caused or aggravated by an increased activity of the phospholipase A2 enzyme, such as inflammations, allergies, asthma, psoriasis and endotoxin shock.
L'invention concerne de nouveaux antiphlogistiques et analgésiques de formules (I) et (II). Ces nouveaux composés présentent une meilleure activité inhibitrice et/ou une plus faible cytotoxicité par rapport aux composés de la technique antérieure. Les composés de l'invention se prêtent remarquablement bien à des applications pour la prévention et/ou le traitement de maladies provoquées totalement ou en partie par un accroissement de l'activité de la phospholipase A2, telles que des inflammations, allergies, asthme, psoriasis et choc endotoxinique.
Goudreau Gage Dubuc
Merckle Gmbh
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