Acylsulfamide inhibitors of factor viia

Details Acylsulfamide inhibitors of factor viia Acylsulfamide inhibitors of factor viia

C - Chemistry, Metallurgy

07

C

C07C 307/06 (2006.01) A61K 31/325 (2006.01) A61K 31/343 (2006.01) A61P 7/02 (2006.01) C07D 307/79 (2006.01)

Patent

CA 2525854

Compounds having the general formula (I) are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties. These compounds may be used in methods of preventing and/or treating clotting disorders.

L'invention concerne des composés de formule générale (I), qui peuvent inhiber des enzymes de la sérine protéase, telles que le facteur tissulaire VIIa, le facteur Xa, la thrombine et la kallikréine, et présentent des propriétés de perméabilité améliorées. Les composés de l'invention peuvent être utilisés dans des méthodes de prévention et/ou de traitement de troubles de la coagulation.

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