Acylsulfonamides as inhibitors of steroid sulfatase

Details Acylsulfonamides as inhibitors of steroid sulfatase Acylsulfonamides as inhibitors of steroid sulfatase

C - Chemistry, Metallurgy

07

C

C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61K 31/439 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61K 31/4535 (2006.01) A61K 31/46 (2006.01) A61P 17/08 (2006.01) A61P 17/10 (2006.01) C07D 211/24 (2006.01) C07D 211/34 (2006.01) C07D 211/48 (2006.01) C07D 211/58 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 211/64 (2006.01) C07D 211/66 (2006.01) C07D 211/70 (2006.01) C07D 211/78 (2006.01) C07D 211/96 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 221/22 (2006.01) C07D 271

Patent

CA 2458453

A compound of formula (I), wherein R1 is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C6-18)aryl, and R1 or R2 independently of each other are substituted (C4-8)cycloalkyl, a substituted bridged cycloalkyl system, substituted piperidine, substituted tetrahydropyridine, or a substituted bridged heterocyclic system, useful as a pharmaceutical.

L'invention concerne des acylsulfonamides représentés par la formule (I), dans laquelle R¿1? représente haloalkyle, alcényle, phényle, thiényle, pyridine, benzothiazolyle, chromanyle (1,2-dihydrobenzopyranyle) ou aryle en (C¿6-18?), et R¿1? ou R¿2? représentent indépendamment cycloalkyle en (C¿4-8?) substitué, un système cycloalkyle ponté substitué, pipéridine substituée, tétrahydropyridine substituée ou un système hétérocyclique ponté substitué ; ce composé est utile comme produit pharmaceutique dans le traitement de troubles dans lesquels intervient la stéroïde sulfatase.

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