C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 333/04 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/265 (2006.01) A61K 31/27 (2006.01) A61K 31/44 (2006.01) A61P 31/18 (2006.01) C07C 323/62 (2006.01) C07C 327/32 (2006.01) C07C 329/10 (2006.01) C07C 333/20 (2006.01) C07D 213/81 (2006.01) C07D 213/83 (2006.01) C12N 7/06 (2006.01)
Patent
CA 2456083
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
L'invention se rapporte à certains composés de thiol et d'acythiol qui inhibent la croissance des rétrovirus en attaquant les zones des doigts de zinc hautement conservées des protéines virales essentielles. L'invention porte sur ces composés, sur des compositions les contenant, ainsi que sur des procédés d'utilisation correspondants afin de traiter des infections rétrovirales telles que le HIV. Ces composés sont également utiles dans la préparation de vaccins contenant des rétrovirus inactivés tels que le HIV, dans le prévention de la transmission de ces rétrovirus, ainsi que dans la détection de protéines rétrovirales.
Appella Ettore
Goel Atul
Inman John K.
Marco Schito
Turpin Jim A.
Sim & Mcburney
The Government Of The United States As Represented By The Secret
LandOfFree
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