Acylurea connected and sulfonylurea connected hydroxamates

Details Acylurea connected and sulfonylurea connected hydroxamates Acylurea connected and sulfonylurea connected hydroxamates

C - Chemistry, Metallurgy

07

C

C07C 275/50 (2006.01) A61K 31/17 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/433 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/64 (2006.01) A61P 35/00 (2006.01) C07C 275/54 (2006.01) C07C 311/58 (2006.01) C07C 311/60 (2006.01) C07C 335/26 (2006.01) C07D 209/14 (2006.01) C07D 213/40 (2006.01) C07D 233/61 (2006.01) C07D 235/14 (2006.01) C07D 285/06 (2006.01) C07D 295/13 (2006.01) C07D 295/215 (2006.01) C07D 307/14 (2006.01) C07D 307/

Patent

CA 2543570

The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.

La présente invention concerne des composés d'hydroxamate qui sont des inhibiteurs de l'histone déacétylase. Plus particulièrement, cette invention concerne des composés contenant de l'acylurée et de la sulfonylurée, ainsi que des procédés permettant de les préparer. Ces composés peuvent être utiles en tant que médicaments pour traiter des troubles proliférants ainsi que d'autres maladies impliquant, liées ou associées aux enzymes présentant des activités d'histone déacétylase.

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