C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61P 3/00 (2006.01) C07D 211/20 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2646588
Novel substituted adamantane based inhibitors of structure (I), their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11-hydroxysteroid dehydro-genase type (1) (11HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
La présente invention concerne de nouveaux inhibiteurs à base d'adamantane substitué et présentant la structure (I), leur utilisation en thérapie, des compositions pharmaceutiques contenant les composés, l'utilisation desdits composés dans la fabrication de médicaments, et des procédés thérapeutiques consistant à administrer lesdits composés. Les présents composés modulent l'activité de la 11-hydroxystéroïde déshydrogénase de type (1) (11HSD1) et ils sont de ce fait utiles dans le traitement de maladies pour lesquelles une telle modulation est bénéfique, telles que le syndrome métabolique.
Ebdrup Soren
High Point Pharmaceuticals Llc
Smart & Biggar
LandOfFree
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