C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) C12N 7/08 (2006.01)
Patent
CA 2365415
The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.
L'invention concerne un procédé qui consiste à répliquer des virus à titrage élevé dans des cellules de mammifères par infection desdites cellules avec une souche de virus à titrage élevé. On obtient ainsi des cellules infectées, en particulier des souches de virus de dengue atténués des sérotypes 1, 2, 3 et 4. Le virus ainsi reproduit peut être utilisé dans des vaccins et des procédés de vaccination qui sont également traités dans l'invention.
Eckels Kenneth H.
Innis Bruce L.
Putnak Joseph R.
Gowling Lafleur Henderson Llp
Walter Reed Army Institute Of Research
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