Adaptive electric field modulation of neural systems

A - Human Necessities – 61 – N

Patent

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A61N 1/36 (2006.01)

Patent

CA 2393535

The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.

La présente invention concerne des dispositifs et des techniques permettant de modifier l'activité neuronale d'un système neuronal comprenant des neurones. Ces techniques comprennent une ou plusieurs des étapes suivantes: mesure de l'activité neuronale d'un système neuronal, application sur ce système neuronal d'un champ électrique orienté efficace pour modifier l'activité neuronale de ce système neuronal, par laquelle la magnitude et la polarité de ce champ électrique appliqué est changée en réponse à l'activité neuronal mesurée. Cette invention concerne aussi des dispositifs et des techniques permettant de traiter des troubles du cerveau, telles que l'épilepsie et la maladie de Parkinson. Ces techniques comprennent une ou plusieurs des étapes suivantes: applicationin situ d'un champ électrique orienté et inférieur à un seuil, au cerveau d'un patient atteint de ces troubles dans une mesure efficace pour réduire l'activité anormale de ce cerveau, ce champ électrique étant appliqué via des électrodes de champ en contact avec le cerveau.

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