Adaptor protein frs2 and related products and methods

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2274145

The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.

L'invention porte d'une manière générale sur une protéine adaptatrice récemment identifiée, la FRS2, et sur des produits et procédés associés. La FRS2 fixe les protéines kinases à des partenaires d'activation de la cellule. L'invention porte également sur des molécules d'acide nucléique codant pour des parties de FRS2, sur des vecteurs d'acide nucléique contenant des molécules d'acide nucléique apparentées à la FRS2, sur des cellules de recombinaison contenant lesdits vecteurs d'acide nucléique, sur des polypeptides purifiés obtenus à partir desdites cellules de recombinaison, sur des anticorps desdits polypeptides, et sur des procédés d'identification de composés renforçant ou bloquant les interactions de la FRS2 avec des partenaires naturels de fixation. L'invention porte en outre sur des procédés de diagnostic des états anormaux d'organismes recourant à des molécules ou composés apparentés à la FRS2.

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