C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.06, 195/12
C07K 5/072 (2006.01)
Patent
CA 1101845
ABSTRACT OF THE DISCLOSURE Addition compounds having the formula Image (I) wherein R1 represents an aliphatic oxycarbonyl group, benzyl- oxycarbonyl group which can have nuclear substituents, or benzoyl, aromatic sulfonyl or aromatic sulfinyl group; R2 represents methyl, isopropyl, isobutyl, isoamyl or benzyl group; R3 represents a lower alkoxyl, benzyloxy or benzhydry- loxy group and n represents 1 or 2. The addition compounds are produced by reacting an N-substituted monoaminodicarboxylic acid having the formula Image (IV) with an amino carboxylic acid ester having the formula Image (V) in an aqueous medium in the presence of a protease and react- ing the resulting dipeptide ester with the amino carboxylic acid ester and separating the addition compound. The addition compounds can be decomposed into the constituent dipeptide esters and amino acid esters by the action of an acid.
295711
Ichikawa Tetsuya
Isowa Yoshikazu
Kihara Keiichi
Mori Kaoru
Nishimura Shigeaki
(zaidanhojin) Sagami Chemical Research Center
Marks & Clerk
Toyo Soda Manufacturing Co. Ltd.
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