Addressable protein arrays

Details Addressable protein arrays Addressable protein arrays

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C03C 17/30 (2006.01) C03C 17/34 (2006.01) C07B 61/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 17/06 (2006.01) C12P 19/34 (2006.01) G01N 33/552 (2006.01)

Patent

CA 2323638

Disclosed herein are arrays of nucleic acid-protein fusions which are immobilized to a solid surface through capture probes which include a non- nucleosidic spacer group and an oligonucleotide sequence to which the fusion (such as an RNA-protein fusion) is bound. Also disclosed herein are solid supports on which these arrays are immobilized as well as methods for their preparation and use (for example, for screening for protein-compound interactions such as protein-therapeutic compound interactions).

On décrit des systèmes fusionnés d'acides nucléiques et de protéines, immobilisés sur une surface solide à travers des sondes de capture incluant un groupe espaceur non nucléotidique, et une séquence oligonucléotidique à laquelle la fusion (fusion ARN-protéine, par exemple) est liée. On décrit également des supports solides sur lesquels ces systèmes sont immobilisés, ainsi que des méthodes concernant leur préparation et utilisation (par exemple, pour un criblage destiné à déclencher des interactions protéine-composé, telles que des interactions d'une protéine et d'un composé thérapeutique).

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