Adduct salts of novel substituted benzylamine and a process...

Details Adduct salts of novel substituted benzylamine and a process... Adduct salts of novel substituted benzylamine and a process...

C - Chemistry, Metallurgy

07

C

C07C 233/47 (2006.01) C07B 57/00 (2006.01) C07C 209/88 (2006.01) C07C 213/10 (2006.01) C07C 217/48 (2006.01) C07C 231/20 (2006.01) C07C 253/34 (2006.01) C07C 255/58 (2006.01) C07C 271/22 (2006.01) C07C 311/19 (2006.01)

Patent

CA 2191685

The invention relates to a process for optical resolution of a racemic substituted benzylamine, which comprises the steps of (a) reacting in a solvent a racemic substituted benzylamine selected from the group consisting of racemic .alpha.-methoxymethylbenzylamines, racemic .alpha.- (substituted phenyl)alkylamines and racemic .alpha.-(substituted phenyl)-alkoxyethylamines, with an optically active N-acyl- phenylalanine, -aspartic acid or -glutamic acid at a temperature sufficient to effect formation of two diastereomeric salts having different solubilities; and (b) separating the diastereomeric salts by selective precipitation of the less soluble of the two diastereomeric salts. The process of the invention permits optical resolution of racemic substituted benzylamines at a high yield in a simple manner using a low cost material as a resolving agent.

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