Adenine derivatives

Details Adenine derivatives Adenine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2347512

The present invention provides compounds of formula (I): Image wherein R1 is alkyl or cyclopropylmethyl; R2 is phenyl-alkylene or naphthyl-alkylene, said alkylene chain being optionally further substituted by phenyl or naphthyl, each phenyl or naphthyl being optionally substituted by one or more substituents each independently selected from alkyl, alkoxy, halo and cyano; n is 1 or 2; A is NR a, NR a C(O), NR a C(O)NR a, NR a C(O)O, OC(O)NR a, C(O)NR a, NR a SO2, SO2NR a, O, S or SO2; R a is H, alkyl or benzyl optionally ring-substituted by one or more substituents each independently selected from alkyl, alkoxy, halo and cyano; R3 is a group of the formula -(CM2)p-R p-B;

L'invention concerne des composés de formule (I), des sels et des solvates de ceux-ci, acceptables au plan pharmaceutique, ainsi que des procédés de préparation de compositions contenant des composés ayant une activité d'agoniste de récepteur d'adénosine A2a, des procédés d'utilisation de ces derniers et des intermédiaires utilisés dans la préparation desdits composés.

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