Adenine derivatives

Details Adenine derivatives Adenine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01) C07D 473/24 (2006.01) C07D 473/34 (2006.01)

Patent

CA 2444130

This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): (see formula I) wherein X represents NR3 (wherein R3 represents a hydrogen atom or C1-3 alkyl) or the like; R1 represents substituted or unsubstituted alkyl or the like; R2 represents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

L'invention concerne des dérivés d'adénine représentés par la formule générale (I) suivante, dans laquelle X représente NR?3¿ (R?3¿ représentant hydrogène ou alkyle C¿1-3?), etc.; R?1¿ représente alkyle facultativement substitué, etc.; R?2¿ représente hydroxy, etc.; et Y représente un hétérocycle aromatique facultativement substitué, etc. L'invention concerne également des tautomères ou des sels pharmaceutiquement acceptables de ces dérivés, ainsi que des médicaments, tels que des agents inducteurs d'interféron, des agents antiviraux, des agents anticancéreux, des inhibiteurs de réponse immunitaire sélectifs de lymphocytes T auxiliaires de type 2, des agents antiallergiques et des agents de contrôle de la réponse immunitaire contenant ces dérivés comme principe actif.

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