Adenine nucleoside derivatives, their preparation and...

Details Adenine nucleoside derivatives, their preparation and... Adenine nucleoside derivatives, their preparation and...

C - Chemistry, Metallurgy

07

H

260/229.5

C07H 19/16 (2006.01) C07D 473/00 (2006.01)

Patent

CA 1157854

ABSTRACT Disclosed herein are novel adenine nucleoside derivatives of the general formula I Image (I) and the pharmaceutically acceptable salts thereof, wherein Q represents oxygen or methylene and Rx, Ry and Rz indepen- dently represent hydrogen or an alkoxyalkanoyl grouping R1-O-R2-CO-, with the provisc that at least one of Rx, Ry and Rz is the alkoxyalkanoyl grouping R1-O-R2-CO-, the alkyl moiety R1 and the alkadiyl moiety R2 each independent- ly containing 1 to 6 carbon atoms. The novel compounds exhibit antiviral activity and their use for this purpose is disclosed. Also disclosed are methods for the preparation of the novel compounds and pharma- ceutical compositions containing them.

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