Adeno-associated viral vector-mediated expression of factor...

Details Adeno-associated viral vector-mediated expression of factor... Adeno-associated viral vector-mediated expression of factor...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2329143

The instant invention provides methods and materials for expressing polypeptides with factor VIII activity comprising administering at least two rAAV vectors encoding different domains of human factor VIII and at least the heavy and light chains.

L'invention concerne des procédés et des matériaux permettant l'expression de polypeptides comprenant une activité facteur VIII. Ces procédés comprennent l'administration d'au moins deux vecteur rAAV codant pour différents domaines du facteur VIII humain et au moins pour les chaînes lourde et légère.

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