Adeno-associated virus (aav) clades, sequences, vectors...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/864 (2006.01) A61K 48/00 (2006.01) C07K 14/015 (2006.01)

Patent

CA 2537793

Sequences of adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.

La présente invention se rapporte à des séquences de nouvelles capsides des virus associés aux adénovirus, ainsi qu'à des vecteurs et à des cellules hôtes contenant lesdites séquences. L'invention concerne également des procédés d'utilisation de tels cellules hôtes et vecteurs pour produire des particules rAAV. L'invention a enfin trait à l'administration assistée par AAV de gènes thérapeutiques et immunogènes à l'aide des vecteurs selon l'invention.

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