Adeno-associated virus (aav) serotype 8 sequences

Details Adeno-associated virus (aav) serotype 8 sequences Adeno-associated virus (aav) serotype 8 sequences

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/015 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2469785

Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.

L'invention se rapporte aux séquences du sérotype 8 du virus associé à l'adénovirus, ainsi qu'à des vecteurs et à des cellules hôtes contenant ces séquences. L'invention concerne aussi des procédés d'utilisation de ces cellules hôtes et des ces vecteurs dans la fabrication de particules de rAAV. L'invention porte également sur l'administration induite par rAAV de gènes thérapeutiques et immunogéniques.

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