Adeno-associated virus vectors and uses thereof

Details Adeno-associated virus vectors and uses thereof Adeno-associated virus vectors and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/64 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2328447

The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

Cette invention concerne une molécule d'ADN isolée et purifiée comprenant au moins un segment d'ADN, une sous-unité biologiquement active ou un variant de cette dernière d'un intermédiaire circulaire de virus adéno-associé, ledit segment d'ADN conférant une meilleure stabilité épisomique, une meilleure persistance ou une meilleure abondance à la molécule d'ADN isolée dans une cellule hôte. Cette invention concerne également une composition qui contient au moins deux vecteurs de virus adéno-associés.

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