Adeno-associated viruses and uses thereof

Details Adeno-associated viruses and uses thereof Adeno-associated viruses and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/864 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2386546

The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

Cette invention se rapporte à une molécule d'ADN isolée et purifiée comprenant au moins un segment d'ADN, une sous-unité biologiquement active ou variante de cette sous-unité, d'un intermédiaire circulaire de virus adéno-associé, ce segment d'ADN assurant une plus grande stabilité, persistance ou abondance épisomique de la molécule d'ADN isolée dans une cellule hôte. Cette invention concerne également une composition comprenant au moins deux vecteurs de virus adéno-associés.

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