Adenosine-5'-carboxylic acid derivatives and process for...

Details Adenosine-5'-carboxylic acid derivatives and process for... Adenosine-5'-carboxylic acid derivatives and process for...

C - Chemistry, Metallurgy

07

H

260/229.5

C07H 19/16 (2006.01)

Patent

CA 1077931

ABSTRACT OF THE DISCLOSURE Adenosine-5'-carboxylic acid derivatives of the formula: Image wherein R1 and R2, which may be the same or different, are hydro- gen atoms, hydroxyl or amino groups or lower alkyl, lower alkenyl, optionally N-alkylated lower aminoalkyl, cycloalkyl or hydroxy- alkyl radicals containing from 1 to 8 carbon atoms, preferably from 1 to 6 carbon atoms, or piperidine residues or R1 and R2 together represent a divalent alkylene radical containing 4 - 7 carbon atoms, which can be interrupted by an oxygen or sulphur atom or by an imino, alkylimino or arylimino radical and Z repre- sents two hydrogen atoms or a lower alkylidene radical are pre- pared by reacting an appropriate adenosine-5'-carboxylic acid re- active derivative with an appropriate amine. The products and their pharmacologically compatible salts, preferably in the form of their pharmaceutical compositions are useful pharmacologically and exhibit a very strong circulatory action.

118018

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