Adenosine a1 receptor agonists

Details Adenosine a1 receptor agonists Adenosine a1 receptor agonists

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) A61K 31/7076 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2309202

A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3alkyl, R2 represents C1-3alkyl, R1 cannot represent phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, -CO2R c, -CONR c R d, -COR c, -SOR e, -SO2R e, -SO3H, -SO2NR c R d, -OR c, -NHSO2R e, -NHCOR c and -NR c R d; and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof. These compounds are agonists at the Adenosine A1 receptor.

L'invention concerne un composé de la formule (I) où: R<2> est alkyle C1-3, halogène, hydrogène; R<3> est un groupe alkyle droit ou ramifié de 1-6 atomes de carbone; à condition que, lorsque R<3> représente alkyle C1-6, R<2> représente alkyle C1-3, R<1> ne peut pas représenter phényle éventuellement substitué au choix par un ou plusieurs substituants choisis parmi halogène, alkyle C1-3, trifluorométhyle, nitro, cyano, -CO2R<c>, -CONR<c>R<d>, -COR<c>, -SOR<e>, -SO2R<e>, -SO3H, -SO2NR<c>R<d>, -OR<c>, -NHSO2R<e>, -NHCOR<c> et -NR<c>R<d>; cette invention se rapportant également à des sels et solvates de ce composé, en particulier à des sels et solvates physiologiquement acceptables. Ces composés sont des antagonistes du récepteur A1 de l'adénosine.

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