Adenosine a1 receptor antagonist for the treatment of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/138 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/403 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/4745 (2006.01) A61K 31/522 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) A61K 45/06 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2516730

Disclosed are pharmaceutical composition comprising a beta-blocker and an adenosine A1 receptor antagonist (AA1RA), an angiotensin converting enzyme (ACE) inhibitor and an adenosine A1 receptor antagonist (AA1RA), and an angiotensin II receptor blocker (ARB) and an adenosine A1 receptor antagonist (AA1RA). Also disclosed are methods of treating cardiovascular disease, renal disease, alkalosis, or diabetic nephropathy comprising identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient.

L'invention concerne une composition pharmaceutique comprenant un bêtabloquant et un antagoniste du récepteur de l'adénosine A¿1? (AA¿1?RA), un inhibiteur de l'enzyme de conversion de l'angiotensine (ACE) et un antagoniste du récepteur de l'adénosine A¿1? (AA¿1?RA), ainsi qu'un bloqueur du récepteur de l'angiotensine II (ARB) et un antagoniste du récepteur de l'adénosine A¿1? (AA¿1?RA). L'invention concerne également des méthodes destinées à traiter une maladie cardiovasculaire, une maladie rénale, l'alcalose ou la néphropathie diabétique, et consistant à identifier un patient nécessitant un tel traitement et à administrer la composition pharmaceutique susmentionnée à ce patient.

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