Adenosine a2a receptor antagonists for the treatment of...

Details Adenosine a2a receptor antagonists for the treatment of... Adenosine a2a receptor antagonists for the treatment of...

A - Human Necessities

61

K

A61K 45/06 (2006.01)

Patent

CA 2625859

There is disclosed a method for the treatment or prevention of Extra Pyramidal syndrome (EPS), dystonia, restless legs syndrome (RLS) or periodic leg movement in sleep (PLMS) comprising the administration of an adenosine A2a receptor antagonist, alone or in combination with other agents useful for treating EPS, dystonia, RLS or PLMS; also claimed are pharmaceutical compositions consisting of an adenosine A2a receptor antagonist in combination with an antipsychotic agent, an anticonvulsant agent, lithium or an opioid.

L'invention concerne une méthode de traitement ou de prévention du syndrome extrapyramidal (EPS), de la dystonie, du syndrome des jambes sans repos (RLS) ou des mouvements périodiques des jambes pendant le sommeil (PLMS), qui consiste à administrer un antagoniste du récepteur A2a de l'adénosine, seul ou associé à d'autres agents utilisés dans le traitement de l'EPS, de la dystonie, du RLS ou des PLMS. De plus, l'invention concerne des compositions pharmaceutiques qui renferment un antagoniste du récepteur A2a de l'adénosine associé à un agent antipsychotique, un agent anticonvulsif, du lithium ou un opioïde.

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