Adenosine analogs useful as anti-bacterial and...

C - Chemistry – Metallurgy – 07 – H

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Details

C07H 19/173 (2006.01) A61K 31/7076 (2006.01) A61P 31/04 (2006.01) C07H 19/167 (2006.01)

Patent

CA 2596142

The present invention is directed to purine nucleoside analogs of the general Formula (I), or tautomers thereof, physiologically acceptable salts, solvents and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful as anti-bacterial and anti-protozoan agents. The invention is also directed to methods for treating a bacterial or protozoan infection in a mammal and use of the compounds for inhibiting the growth of a bacteria or protozoa.

La présente invention concerne des analogues nucléosidiques puriques de formule générale (I), ou des tautomères de ces derniers, des sels physiologiquement acceptables, des solvants et des dérivés physiologiquement fonctionnels de ces derniers, ainsi que des compositions pharmaceutiques comprenant lesdits composés, sels et dérivés, utiles comme agents antibactériens et antiprotozoaires. Cette invention concerne également des méthodes pour traiter une infection bactérienne ou protozoaire chez un mammifère et l'utilisation desdits composés pour inhiber la croissance d'une bactérie ou d'un protozoaire.

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