A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 45/00 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01) C07D 473/34 (2006.01) C07H 19/14 (2006.01)
Patent
CA 2213749
Disclosed are adenosine A2 receptor agonists for use in increasing the contractile performance of a compromised myocardium in a mammal. The agonists are administered in a therapeutically effective amount. Also disclosed are additional compounds, e.g., an adenosine transport inhibitor, an inhibitor of adenosine metabolism or an adenosine A1 receptor antagonist, that potentiate the beneficial effect of the adenosine A2 receptor agonist when administered in conjunction with the agonist.
On décrit des agonistes des récepteurs de l'adénosine A¿2? utilisables pour augmenter la capacité de contraction d'un myocarde malade chez un mammifère. Les agonistes sont administrés en une dose thérapeutique efficace. On décrit également des composés additionnels, tels qu'un inhibiteur du transport de l'adénosine, un inhibiteur du métabolisme de l'adénosine ou un antagoniste des récepteur de l'adénosine A¿1?, qui renforcent les effets bénéfiques de l'agoniste des récepteurs de l'adénosine A¿2?, lorsqu'ils sont administrés conjointement.
Smart & Biggar
University Of Massachusetts Medical Center
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