Adenosine derivatives

Details Adenosine derivatives Adenosine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2186847

Compounds of formula (I), wherein R1 is one of a number of significances, including cycloalkyl and hydroxycycloalkyl; R2 is hydrogen, (C1-4)alkyl, amino, (C3-5)cycloalkyl or halogen with an atomic number of 9 to 35, and R3 is (C1-4)alkyl, are useful as analgesic agents. Compounds of formula (I) wherein R1 is hydroxy alkyl are new. The compounds of formula (I) may be produced by alkylation in the 2' position in the presence of tetrabutylammonium hydrogen sulfate and a non-polar solvent.

Composés de la formule (I) dans laquelle R¿1? a plusieurs notations possibles, notamment cycloalkyle et hydroxycycloalkyle; R¿2? représente hydrogène, alkyle (C¿1-4?), amino, cycloalkyle (C¿3-5?) ou halogène d'un numéro atomique compris entre 9 et 35, et R¿3? représente alkyle (C¿1-4?). Ces composés sont utiles comme agents analgésiques. Les composés de la formule (I), dans laquelle R¿1? représente hydroxy-alkyle, sont nouveaux, et peuvent être produits par alkylation en position 2' en présence de sulfate d'hydrogène de tétrabutylammonium et d'un solvant non polaire.

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