Adenosine derivatives having a2a receptor activity

Details Adenosine derivatives having a2a receptor activity Adenosine derivatives having a2a receptor activity

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/7076 (2006.01) A61P 9/00 (2006.01) C07D 473/00 (2006.01) C07D 473/16 (2006.01)

Patent

CA 2598865

Compounds of (I), or stereoisomers or pharmaceutically acceptable salts thereof, where W, R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

La présente invention concerne des composés de (1) stéréoisomères ou des sels pharmaceutiquement acceptables de ceux-ci, où W, R1, R2, R3 et R4 désignent des éléments définis dans la description de la présente demande. Ces composés sont utiles pour le traitement de troubles induits par l~activation du récepteur A2A de l~adénosine, en particulier des maladies inflammatoires et obstructives des voies respiratoires. L~invention concerne également des compositions pharmaceutiques contenant les composés de l~invention, ainsi que des procédés destinés à la préparation de ces composés.

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