A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61P 7/02 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2368099
The present invention relates to materials and methods for the diagnosis and treatment of pre-eclampsia and related conditions characterised by platelet aggregation. In particular it relates to the use of adenosine diphosphatase (ADPase) and activators of ADPase for the treatment of pre-eclampsia, in order to overcome the inhibition of ADPase by inositol phosphoglycans (IPGs). Also provided is a method for screening for compounds with ADPase-stimulatory activity in the presence or absence of IPGs.
La présente invention concerne des matériaux et des procédés pour diagnostiquer et traiter la pré-éclampsie et les pathologies associées caractérisées par l'agrégation plaquettaire. Elle concerne, en particulier, l'utilisation d'adénosine diphosphatase (ADPase) et d'activateurs d'ADPase pour le traitement de la pré-éclampsie, de manière à surmonter l'inhibition de l'ADPase par inositolphosphoglycane (IPG). L'invention porte également sur un procédé de criblage de composés présentant une activité de stimulation d'ADPase en présence ou en l'absence d'IPG.
Greenbaum Leslie
Mclean Patricia
Rademacher Thomas William
Bereskin & Parr
Greenbaum Leslie
Mclean Patricia
Rademacher Thomas William
Rademacher Group Limited
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