Adenosine re-uptake inhibiting derivatives of diphenyl...

Details Adenosine re-uptake inhibiting derivatives of diphenyl... Adenosine re-uptake inhibiting derivatives of diphenyl...

C - Chemistry, Metallurgy

07

D

C07D 413/02 (2006.01) A61K 31/495 (2006.01) C07D 233/54 (2006.01) C07D 235/14 (2006.01) C07D 263/32 (2006.01) C07D 277/28 (2006.01) C07D 403/02 (2006.01) C07D 403/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/02 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2101311

Abstract A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

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