Adenosine uptake inhibitor

Details Adenosine uptake inhibitor Adenosine uptake inhibitor

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/505 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2118117

-109- ABSTRACT The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): Image (I) wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R2, R3, R4, and R5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R6, R7, R8, and R9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R11 (wherein R11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen), or a pharmaceutically acceptable salt thereof as an active ingredient.

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