Adenoviral transfer vector for the gene transport of a dna...

Details Adenoviral transfer vector for the gene transport of a dna... Adenoviral transfer vector for the gene transport of a dna...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2261183

An adenoviral transfer vector for the gene transport of a DNA sequence, which is produced from an adenoviral plasmid which no longer expresses any natural adenoviral proteins and comprises a) a first DNA sequence with the left inverted terminal repeat (ITR) sequence and a packaging signal of the wild-type adenovirus (serotype 5) and b) a second DNA sequence with the right inverted terminal repeat (ITR) sequence of the wild-type adenovirus (serotype 5) and c) cleavage sites for restriction endonucleases which do not occur in the therapeutic genes and/or marker genes to be incorporated between the adenoviral DNA sequences, and preferably d) the ITRs are enclosed by cleavage sites of a restriction endonuclease which cuts but rarely (i.e. the recognition sequence in ~ 8 base pairs), preferybly Fsel, which makes it possible to cut out the adenoviral portion of the transfer vectors, is described.

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