Adenoviral vector-based foot-and-mouth disease vaccine

Details Adenoviral vector-based foot-and-mouth disease vaccine Adenoviral vector-based foot-and-mouth disease vaccine

A - Human Necessities

61

K

A61K 39/135 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2629163

The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector.

L'invention concerne un vecteur adénoviral comprenant au moins une séquence d'acides nucléiques codant un antigène et/ou une cytokine de l'aphtovirus fonctionnellement reliée à un promoteur. Le vecteur adénoviral est déficient pour la réplication et nécessite tout au plus d'être complété tant par la région E1 que par la région E4 du génome adénoviral pour pouvoir se propager. L'invention se rapporte également à un procédé qui permet d'induire une réponse immunitaire chez un mammifère, lequel procédé consiste à administrer au mammifère une composition renfermant le vecteur adénoviral précité.

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