C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 39/015 (2006.01) C07K 14/445 (2006.01)
Patent
CA 2620495
The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.
L'invention concerne des vecteurs adénoviraux constitués d'un génome adénoviral contenant des séquences nucléotidiques codant pour un antigène hétérologue, telles que des séquences nucléotidiques de Plasmodium, liées fonctionnellement à des promoteurs. Cette invention concerne également un procédé pour induire une réponse immunitaire contre la malaria chez un mammifère, qui consiste à administrer ces vecteurs adénoviraux au mammifère.
Bruder Joseph T.
Carucci Daniel John
Doolan Denise Louise
Ettyreddy Damodar R.
King C. Richter
Genvec Inc.
Ridout & Maybee Llp
The Henry M. Jackson Foundation For The Advancement Of Military Inc.
The United States Of America As Represented By The Secretary Of The Nav Y. Naval Medical Rese
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