C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2589602
The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
L'invention concerne une méthode d'induction d'une réponse immunitaire chez un mammifère. Cette méthode consiste à administrer à un mammifère un vecteur adénoviral comprenant (a) une protéine de fibre de sous-groupe C, dans laquelle un virus coxsackie natif et un site de liaison de récepteur d'adénovirus (CAR) est interrompu, (b) une protéine de base de penton de sous-groupe C dans laquelle un site de liaison d'intégrine native est interrompu, et (c) une séquence d'acide nucléique codant au moins un antigène dérivé d'un agent infectieux autre qu'un adénovirus exprimé dans le mammifère, pour induire une réponse immunitaire.
Cheng Cheng
Gall Jason G. D.
Nabel Gary J.
Wickham Thomas J.
Genvec Inc.
Ridout & Maybee Llp
The Government Of The United States Of America As Represented By Department Of Health And Human Services
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