Adenoviral vectors for mutants of human interleukin 6...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/24 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01) C07K 14/54 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266743

The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction. The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL- 6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction.

La présente invention porte sur des adénovirus défectueux recombinants contenant une séquence d'ADN hétérologue codant une mutéine ayant l'action antagoniste ou supra-antagoniste sur l'interleukine-6 humaine (hIL-6). La présente invention porte également sur les utilisations thérapeutiques de ces adénovirus, en particulier en vue de la préparation de compositions pharmaceutiques pour le traitement et/ou la prévention de pathologies dues à une surproduction de hIL-6. Les adénovirus défectueux recombinants de la présente invention contiennent une séquence d'ADN hétérologue codant une mutéine ayant l'action antagoniste ou supra-antagoniste sur l'interleukine-6 humaine (hIL-6). L'invention porte également sur les utilisations thérapeutiques de ces adénovirus, en particulier dans le cadre de la préparation de compositions pharmaceutiques destinées au traitement et/ou à la prévention de pathologies dues à une surproduction de hIL-6.

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